Review: The maturation of a key inflammatory axis in cardiovascular disease
The groups of Prof. Stroes (Amsterdam) and Prof. Nahrendorf (Boston) reviewed recent advances in the connection between hematopoiesis and atherogenesis.
Atherogenesis is the result of a complex interplay between lipids and innate immune cells, which are descendants of upstream progenitors residing in hematopoietic organs.
The relevance of a neural–hematopoietic axis was recently supported by the demonstration of a correlation between metabolic activity in the amygdala and the bone marrow. During follow-up, both amygdalar and bone marrow activities also predicted cardiovascular risk in patients, lending further support to a connection between neural stress and cardiovascular events mediated via increased hematopoietic activity. In parallel, functional changes in hematopoietic stem cells may also convey cardiovascular risk. In experimental models, knock-out of the ten–eleven translocation 2 (TET2) gene leading to monocyte– macrophage hyperresponsiveness, was associated with accelerated atherogenesis in murine experiments. In humans, whole-exome sequencing reporting on the ‘clonal hematopoiesis of indeterminate potential’ gene substantiated a two-fold elevated risk for developing coronary heart disease compared with noncarriers.
In summary, recent studies support the relevance of a ‘neural–hematopoietic’ inflammatory axis and clonal hematopoiesis as drivers of atherogenesis in humans. These data warrant further studies addressing the role of novel ‘hematopoietic’ targets for the treatment of patients with increased cardiovascular risk.
Find the publication here or DOI:10.1097/MOL.0000000000000457