Remnant cholesterol elicits arterial wall inflammation

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The groups of AMC (the Netherlands) and REGIONH (Denmark) collaborated on elucidating the mechanisms by which remnant cholesterol particles may induce inflammatory changes. Remnant cholesterol can be readily taken up by plaque macrophages without previous oxidation of the particle, thereby promoting arterial inflammation. This reaction propagates continued influx of circulating immune cells, predominantly monocytes, into atherosclerotic lesions in both experimental models8 and patients, leading to a multilevel inflammatory response.

 

The main results of this paper provides important novel pathophysiological insights in the atherogenicity of remnant cholesterol, showing increased arterial inflammation and bone marrow activation in patients with elevated levels of remnant cholesterol. These findings indicate an important multilevel inflammatory component to the atherogenicity of remnant cholesterol, which may contribute to its relation with increased cardiovascular risk.

 

This paper can be found here (DOI: 10.1161/ATVBAHA.116.308834).

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.