Promising imaging results published on multi-level inflammatory responses in acute coronary syndrome.

In the first 6–9 months following an acute coronary syndrome (ACS), patients face a disproportionally increased risk of reinfarction. Following an ACS in patients, studies have substantiated that 18F-fluordeoxyglucose (18F-FDG) uptake in bone-marrow and spleen is increased, visualized with positron emission tomography/ computed tomography (PET/CT). This increased uptake coincides with increased inflammatory parameters in plasma and arterial wall inflammation. Whether this multi-level inflammatory response persists after the acute phase, thereby potentially contributing to the increased reinfarction risk post-ACS, is elucidated by this study. The full study report is published in the European Journal of Nuclear Medicine and Molecular Imaging (2018).

 

The AMC group showed with 18F-DPA-714 PET/CT an ACS-triggered hematopoietic organ activation as initiator of a prolonged leukocyte oversupply, characterized by an elevated number of circulating leukocytes and their precursors. Further studies are required to determine whether strategies aimed at reducing this prolonged hematopoietic activation may translate into a reduced re-infarction rate in the vulnerable post-ACS period.

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Full results of this study can be found here or https://doi.org/10.1007/s00259-018-4038-8

 

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.