Grant application OPERATION funded by European Research Area Network on Cardiovascular Diseases (ERA-CVD)

Prof. Erik Stroes (AMC, Amsterdam) and Prof. Alberico Catalano (UMIL, Italy) have teamed up with Prof. Wolfgang Koenig (TUM, Munich) and prepared a successful  transnational ERA-CVD research application entitled OPERATION.

The OPERATION project aims to combine state-of-the-art genome-scale metabolic modelling on plasma monocytes with plasma proteomics to select a biomarker pattern correlating with arterial wall inflammation. Subsequently, advanced machine-learning will be applied to optimize a biomarker pattern predicting cardiovascular risk, which will be validated in primary and secondary prevention cohorts available to this consortium. The end-result is the delivery of a clinically relevant and industrially usable integrated inflammatory plasma biomarker pattern which will enable us to accurately identify patients at residual inflammatory cardiovascular risk.


The OPERATION project is highly complementary to the work performed in the REPROGRAM project. Dedicated actions/meetings will be organized to create synergy and exchange data, knowledge and infrastructures. The OPERATION project will start on 1 July 2018 with a duration of 36 months.

Schematic overview of the OPERATION project:Schermafbeelding 2018-02-23 om 14.45.48

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.