Grant application MEMORY funded by European Research Area Network on Cardiovascular Diseases (ERA-CVD)
Prof. Niels RIksen (RadboudUmc, Nijmegen) teamed up with dr. Andreas Schlitzer (University of Bonn, Germany) and dr. Hafid Ait-Oufella (St-Antoine Hospital and Inserm , France). They prepared a successful transnational ERA-CVD research application entitled MEMORY.
Due to the worldwide adoption of Western lifestyle, the prevalence of obesity increases exponentially. Obesity is an important risk factor for atherosclerotic cardiovascular disease, including heart attacks and strokes. The ultimate aim of this proposal is to understand how Western type diet and obesity induce atherosclerosis.
They focus on the innate immune system, since this importantly contributes to atherosclerosis and they have recently shown that substances that can induce cardiovascular disease (such as cholesterol particles) can lead to a long-term activation of the innate immune system.
They propose that Western type diet and obesity changes the development of the innate immune system in the bone marrow in such a way that they are prone to stimulate the development of atherosclerosis.
Their results potentially can reveal novel mechanism that contribute to cardiovascular disease in subjects with obesity that can be used to develop novel drugs to prevent these diseases
The MEMORY project is highly complementary to the work performed in the REPROGRAM project. Dedicated actions/meetings will be organized to create synergy and exchange data, knowledge and infrastructures.