Christ 20161

Epigenetic remodeling and the use of ‘epigenetic drugs’ are a promising tool for future treatment of atherosclerosis.

Bonn University (Prof. Eike Latz) and Radboud University Medical Center Nijmegen (Prof. Niels Riksen and Dr. Siroon Bekkering) published a review in the journal Seminars on Immunology in which they discuss the concept of trained innate immunity in the context of a hyperlipidemic environment and atherosclerosis. According to this idea the epigenome of myeloid (progenitor) cells is presumably modified for prolonged periods of time, which, in turn, could evoke a condition of continuousimmune cell over-activation.

Christ 2016

Figure: Cellular stressors can influence the epigenetic landscape of innate immune cells. This may lead to different immune responses of the cells towards secondary stimuli, a concept that has been termed ‘innate immune memory’, with alternative fates being polarization, cell death or increased proliferation.

You can find the full open access article here.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.