Epigenetic remodeling and the use of ‘epigenetic drugs’ are a promising tool for future treatment of atherosclerosis.
Bonn University (Prof. Eike Latz) and Radboud University Medical Center Nijmegen (Prof. Niels Riksen and Dr. Siroon Bekkering) published a review in the journal Seminars on Immunology in which they discuss the concept of trained innate immunity in the context of a hyperlipidemic environment and atherosclerosis. According to this idea the epigenome of myeloid (progenitor) cells is presumably modified for prolonged periods of time, which, in turn, could evoke a condition of continuousimmune cell over-activation.
Figure: Cellular stressors can influence the epigenetic landscape of innate immune cells. This may lead to different immune responses of the cells towards secondary stimuli, a concept that has been termed ‘innate immune memory’, with alternative fates being polarization, cell death or increased proliferation.
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