Publication in Circulation Aug 05-2016: Oxidized phospholipids on lipoprotein(a) elicit arterial wall inflammation and an inflammatory monocyte response in humans.

Circulation publication Aug 2016 Van der ValkIn this translational work, we provide evidence in support of the concept that pro inflammatory oxidized phospholipids are major contributors to the atherogenicity of Lipoprotein(a) [Lp(a)] by showing that (1) subjects with elevated Lp(a) have increased arterial inflammation in vivo, (2) monocytes isolated from subjects with elevated Lp(a) remain in a long-lasting activated state ex vivo, and (3) Lp(a) elicits the proinflammatory response in healthy monocytes in vitro, an effect markedly attenuated by removing or inactivating OxPLs present on Lp(a) and specifically on apo(a).


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This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.