Stienstra 20171

Cell Metabolism review: Importance of cellular metabolic rewiring during myeloid cell activation

Renewed interest in immune cell metabolism has led to the emergence of a research field aimed at studying the importance of metabolic processes for an effective immune response. In addition to the adaptive immune system, cells of the myeloid lineage have been shown to undergo robust metabolic changes upon activation.

In the Cell Metabolism paper, published by the groups of Prof. Netea, Prof. Joosten and Prof. Riksen of Radboud University Medical Center Nijmegen, an overview is presented of the metabolic heterogeneity in activated myeloid cells during health and disease. Directions for future research are suggested to ultimately provide new therapeutic opportunities. The uniqueness of metabolic signatures accompanying different conditions will require tailor-made interventions to ultimately modulate aberrant myeloid cell activation during disease.

Stienstra 2017

Figure: Schematic overview of our current knowledge on myeloid cell metabolism during disease.

The full article can be read here.

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.