Category: Publications

post image

Scientific publication in European Heart Journal

Sophie J. Bernelot Moens, junior researcher in the group of Prof. Erik Stroes and Prof. Menno de Winther (Academic Medical Center) recently published her results in European Heart Journal on how PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia. Proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies increase hepatic low-density lipoprotein receptor expression and show potent low-density lipoprotein

Read More →

post image

Review on the biology of PCSK9 in Cardiovascular Research

The group of Prof. Catapano at University of Milano, Italy (IRCCS MultiMedica-MultiMedica SpA, Cardiovascular Department, Atherosclerosis Center) published an highly interesting review on the biological processes of Proprotein Convertase Subtilisin Kexin 9 (PCSK9). PCK9 is a key regulator of low-density lipoprotein receptor levels and LDL-cholesterol levels. The PCSK9 gene is associated with hypocholesterolaemia and protection against cardiovascular disease, setting the stage for

Read More →

post image

New CELL METABOLISM paper by the groups of Radboud University Nijmegen

The groups of Riksen, Joosten and Netea investigated the induction of trained immunity (innate immune memory) and the role of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Trained immunity is the key mechanism studied in REPROGRAM and proposed as a common diseases mechanism underlying atherosclerosis and rheumatoid arthritis.   The study published in CELL

Read More →

post image

New scientific publication in Clinical and Vaccine Immunology

Bekkering et al determined the optimal conditions for an in vitro experimental protocol of monocyte training using three of the most commonly used training stimuli from the literature: -glucan, BCG vaccine, and oxLDL. Although the effects of these three stimuli on trained immunity have been described before, this is the first time that the kinetics of this in vitro model have

Read More →

post image

Long-term activation of the innate immune system in atherosclerosis

Efforts to reverse the pathologic consequences of vulnerable plaques are often stymied by the complex treatment resistant pro-inflammatory environment within the plaque. This suggests that pro-atherogenic stimuli, such as LDL cholesterol and high fat diets may impart longer lived signals on (innate) immune cells that persist even after reversing the pro-atherogenic stimuli. Recently, a series

Read More →

post image

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy

Background: Increasing numbers of patients (up to 40 %) with rheumatoid arthritis (RA) achieve remission, yet it remains to be elucidated whether this also normalizes their cardiovascular risk. Short-term treatment with TNF inhibitors lowers arterial wall inflammation, but not to levels of healthy controls. We investigated whether RA patients in long-term remission are characterized by

Read More →

post image

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo.

BACKGROUND AND AIMS: We have recently reported that monocytes can undergo functional and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after brief in vitro exposure to atherogenic stimuli such as oxidized LDL. This process is termed ‘trained immunity’, and is mediated by epigenetic remodeling and a metabolic switch towards increased aerobic glycolysis. We hypothesize that

Read More →

post image

In-vitro experimental model of trained innate immunity in human primary monocytes.

BACKGROUND: Innate immune memory or ‘trained immunity’ has recently been described as an important property of cells of the innate immune system. Due to the increased interest in this important new field of immunological investigation we sought to determine the optimal conditions for an in-vitro experimental protocol of monocyte training using three of the most

Read More →

post image

Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?

Diabetes strongly predisposes to cardiovascular disease (CVD), the leading cause of mortality in these patients, as well as in the entire population. Hyperglycemia is an important cardiovascular risk factor as shown by the observation that even transient periods of hyperglycemia, despite return to normoglycemia during follow-up, increase the risk for CVD, a phenomenon termed ‘hyperglycemic

Read More →

Publication in Circulation Aug 05-2016: Oxidized phospholipids on lipoprotein(a) elicit arterial wall inflammation and an inflammatory monocyte response in humans.

In this translational work, we provide evidence in support of the concept that pro inflammatory oxidized phospholipids are major contributors to the atherogenicity of Lipoprotein(a) [Lp(a)] by showing that (1) subjects with elevated Lp(a) have increased arterial inflammation in vivo, (2) monocytes isolated from subjects with elevated Lp(a) remain in a long-lasting activated state ex

Read More →

1 2

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.