Category: Publications

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The link between hematopoiesis and atherosclerosis

REPROGRAM Principal Investigators working at Amsterdam University Medical Center and Ludwig Maximilians University, Munich published their expert comments on the link between hematopoiesis and atherosclerosis, based on the following article “AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate” in Science. 2019.  There is mounting evidence that atherosclerosis is driven not just by dyslipidemia

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Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides.

Most DAMPs in inflammatory diseases are TLR2- and TLR4-ligands and according to the current concept, repeated stimuli would result in tolerance. Aims of the study were to verify this assumption, to investigate whether epigenetic effectors are involved and to explore the situation in rheumatoid arthritis (RA).

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New scientific article in Cell metabolism 2019.

Patients with hypercholesterolemia have an increased risk for atherosclerotic cardiovascular disease, and despite lipid lowering with statins, an important residual risk remains. We hypothesize that this is due to persistent pro-inflammatory reprogramming of circulating monocytes. Monocyte derived macrophages are key components of atherosclerotic plaques. These cells can build a long-term pro-inflammatory phenotype after brief exposure

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Grant application MEMORY funded by European Research Area Network on Cardiovascular Diseases (ERA-CVD)

Prof. Niels RIksen (RadboudUmc, Nijmegen) teamed up with dr. Andreas Schlitzer (University of Bonn, Germany)  and dr. Hafid Ait-Oufella (St-Antoine Hospital and Inserm , France). They prepared a successful  transnational ERA-CVD research application entitled MEMORY. Due to the worldwide adoption of Western lifestyle, the prevalence of obesity increases exponentially. Obesity is an important risk factor for

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Analyses in the primary prevention setting substantiate that LDL-C and Lp(a) are independently associated with CVD risk.

Lipoprotein(a) (Lp(a)) elevation is a causal risk factor for cardiovascular disease. It has however been suggested that elevated Lp(a) causes cardiovascular disease mainly in individuals with high low-density lipoprotein cholesterol (LDL-C) levels. Therefore it was hypothesized that the risk associated with high Lp(a) levels would largely be attenuated at low LDL-C levels. Results from the Copenhagen City Heart

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Review article on potential epigenetic compounds that could be utilized to prevent or treat atherosclerosis.

In a collaborative effort between the groups of Vascular Medicine and Medical Biochemistry of the Academic Medical Center (Prof. Erik Stroes, Prof. de Winther) a review article has been published in the esteemed Athersclerosis journal (Oct, 2018). In this review, potential epigenetic compounds are studied that could be utilized to prevent or treat atherosclerosis based on

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Promising imaging results published on multi-level inflammatory responses in acute coronary syndrome.

In the first 6–9 months following an acute coronary syndrome (ACS), patients face a disproportionally increased risk of reinfarction. Following an ACS in patients, studies have substantiated that 18F-fluordeoxyglucose (18F-FDG) uptake in bone-marrow and spleen is increased, visualized with positron emission tomography/ computed tomography (PET/CT). This increased uptake coincides with increased inflammatory parameters in plasma

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A new Cell paper on the effects of Western diet on innate immune cell reprogramming

The group from Radboud UMC (Prof. N. Riksen, Prof. M. Netea) co-authored a paper published in Cell earlier this year (11 January 2018) in which work from the REPROGRAM project is mentioned. Today, in Western societies, over 80% of deaths are due to non-communicable diseases including those associated with aging and diseases caused or influenced by the consumption of

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Inhibition of CD40-TRAF6 interactions appaers a potent and selective therapeutic targeting strategy for treating cardiovascular disease.

The interaction between the different immune cells, and the (subsequent) secretion of immune-regulatory and activating cytokines and chemokines determines the progression of atherosclerosis. Key players in modulating these complex immune interactions and responses are the group of co-stimulatory molecules. The group of Prof. Lutgens (LMU) et al found that inhibition of the co-stimulatory molecules CD40L and

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A causal role for remnant cholesterol in cardiovascular disease revealed.

REPROGRAM researchers of the Academic Medical Center (AMC) teamed up with researchers from Copenhagen, Denmark (REGIONH) to study the impact of remnant cholesterol on arterial wall inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD). Although the population with FD is an extreme model, elevated levels of (nonfasting) remnant cholesterol are present in 38% of men and

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This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.