Category: Geen categorie

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A causal role for remnant cholesterol in cardiovascular disease revealed.

REPROGRAM researchers of the Academic Medical Center (AMC) teamed up with researchers from Copenhagen, Denmark (REGIONH) to study the impact of remnant cholesterol on arterial wall inflammation, circulating monocytes, and bone marrow in patients with familial dysbetalipoproteinemia (FD). Although the population with FD is an extreme model, elevated levels of (nonfasting) remnant cholesterol are present in 38% of men and

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Nile Red Quantifier: a novel and quantitative tool to study lipid accumulation in patient-derived circulating monocytes using confocal microscopy.

In a collaborative effort of the teams of Academic Medical Center and Servier a novel tool to study lipid accumulation has been developed. The inflammatory profile of circulating monocytes is an important biomarker for atherosclerotic plaque vulnerability. Recent research revealed that peripheral lipid uptake by monocytes alters their phenotype toward an inflammatory state and this

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Cell paper published by the Radboud and Cluj-Napoca groups on the cholesterol synthesis pathway,

Bekkering et al (2018) published their groundbreaking results on the cholesterol synthesis pathway, and in particular the intermediate mevalonate. This pathway is essential for inducing trained innate immunity, the key-concept of REPROGRAM. Highlights Induction of trained immunity by beta-glucan depends on intracellular mevalonate Mevalonate induces trained immunity in human monocytes Mevalonate-induced training is mediated through increased function of

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This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.