A new Cell paper on the effects of Western diet on innate immune cell reprogramming
The group from Radboud UMC (Prof. N. Riksen, Prof. M. Netea) co-authored a paper published in Cell earlier this year (11 January 2018) in which work from the REPROGRAM project is mentioned.
Today, in Western societies, over 80% of deaths are due to non-communicable diseases including those associated with aging and diseases caused or influenced by the consumption of Western-type calorically rich diets, such as type II diabetes, obesity, and cardiovascular diseases.
The key-finding from this comprehensive study was that systemic inflammation induced by a Western diet is largely blunted by dietary changes, but myeloid cell-induced innate immune responses remain augmented and could potentially contribute to inflammatory disease.
Full results of this study can be found here or https://doi.org/10.1016/j.cell.2017.12.013.