Welcome to the Horizon 2020 atherosclerosis research program website
REPROGRAM open data repository
Now that the REPROGRAM has come to an end, a complete data repository comprising all generated data sets has been set-up and posted on the datasets webpage of the REPROGRAM website (see http://reprogram-horizon2020.eu/data-availability/).
Highly interesting paper published by Nahrendorf et al (Immunity 2019) on tissue-specific macrophage responses to remote injury.
Taking an organism-wide perspective, we describe that macrophages react to infectious or distant ischemic stimuli. A priori, we expected variation in how different tissue-resident macrophages respond to disparate injuries. Gene expression profiles of macrophages in different tissue vary at baseline already, affecting cellular reaction to systemic cytokines. In addition, immune and stromal cell content varies
Final REPROGRAM meeting
On 4 December 2019 the final REPROGRAM meeting was held in the Sheraton. Throughout the final presentations of REPROGRAM partners we concluded that the project was a major success! With large appreciation to the European Union to support us in this large collaborative project we look forward to a promising future in cardiovascular and rheumatoid
Nature Medicine 2019 paper by the Nahrendorf group on the protective effects of exercise against cardiovascular disease.
The Center for Systems Biology of Massachusetts General Hospital (Boston, USA), beneficiary in the REPROGRAM consortium, published a high impact paper on how exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Even though cardiovascular therapeutics have advanced rapidly, the number of patients globally with atherosclerosis and its complications is
In Cluj (Romania), we recruited a cohort of 250 patients with established symptomatic stable coronary artery disease.
In Cluj (UMF, Romania), we recruited a cohort of 250 patients with established symptomatic stable coronary artery disease, angiographically documented coronary atherosclerosis, and no past history of acute thrombotic events (acute myocardial infarction, stroke, acute limb ischemia). We performed clinical follow up for 2 years. In addition to the baseline clinical characteristics, we have isolated
2019 ERC Proof of Concept grant for Prof. Esther Lutgens
Under the European Research Council Proof of Concept grant initiative, ERC grantees may now also apply for additional funding to set up, namely, an Intellectual Property Rights (IPR) strategy for the results of their prior ERC project. The funds are granted at the earliest stage of innovation and therefore researchers now have the necessary support
Interesting data from the Copenhagen General Population Study on the effects of smoking on white and red blood cell count.
A Mendelian Randomization Approach in the Copenhagen General Population Study was conducted to assess whether tobacco smoking causally affects white and red blood cells and thrombocyte counts is unknown. Using this approach, the Copenhagen University Hospital, partner in the REPROGRAM project, tested the hypothesis that smoking causes increases in these blood cell indices. They included
The link between hematopoiesis and atherosclerosis
REPROGRAM Principal Investigators working at Amsterdam University Medical Center and Ludwig Maximilians University, Munich published their expert comments on the link between hematopoiesis and atherosclerosis, based on the following article “AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate” in Science. 2019. There is mounting evidence that atherosclerosis is driven not just by dyslipidemia
Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides.
Most DAMPs in inflammatory diseases are TLR2- and TLR4-ligands and according to the current concept, repeated stimuli would result in tolerance. Aims of the study were to verify this assumption, to investigate whether epigenetic effectors are involved and to explore the situation in rheumatoid arthritis (RA).
New scientific article in Cell metabolism 2019.
Patients with hypercholesterolemia have an increased risk for atherosclerotic cardiovascular disease, and despite lipid lowering with statins, an important residual risk remains. We hypothesize that this is due to persistent pro-inflammatory reprogramming of circulating monocytes. Monocyte derived macrophages are key components of atherosclerotic plaques. These cells can build a long-term pro-inflammatory phenotype after brief exposure
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.
