Welcome to the Horizon 2020 atherosclerosis research program website
Taking an organism-wide perspective, we describe that macrophages react to infectious or distant ischemic stimuli. A priori, we expected variation in how different tissue-resident macrophages respond to disparate injuries. Gene expression profiles of macrophages in different tissue vary at baseline already, affecting cellular reaction to systemic cytokines. In addition, immune and stromal cell content varies
On 4 December 2019 the final REPROGRAM meeting was held in the Sheraton. Throughout the final presentations of REPROGRAM partners we concluded that the project was a major success! With large appreciation to the European Union to support us in this large collaborative project we look forward to a promising future in cardiovascular and rheumatoid
The Center for Systems Biology of Massachusetts General Hospital (Boston, USA), beneficiary in the REPROGRAM consortium, published a high impact paper on how exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Even though cardiovascular therapeutics have advanced rapidly, the number of patients globally with atherosclerosis and its complications is
In Cluj (UMF, Romania), we recruited a cohort of 250 patients with established symptomatic stable coronary artery disease, angiographically documented coronary atherosclerosis, and no past history of acute thrombotic events (acute myocardial infarction, stroke, acute limb ischemia). We performed clinical follow up for 2 years. In addition to the baseline clinical characteristics, we have isolated
Under the European Research Council Proof of Concept grant initiative, ERC grantees may now also apply for additional funding to set up, namely, an Intellectual Property Rights (IPR) strategy for the results of their prior ERC project. The funds are granted at the earliest stage of innovation and therefore researchers now have the necessary support
A Mendelian Randomization Approach in the Copenhagen General Population Study was conducted to assess whether tobacco smoking causally affects white and red blood cells and thrombocyte counts is unknown. Using this approach, the Copenhagen University Hospital, partner in the REPROGRAM project, tested the hypothesis that smoking causes increases in these blood cell indices. They included
REPROGRAM Principal Investigators working at Amsterdam University Medical Center and Ludwig Maximilians University, Munich published their expert comments on the link between hematopoiesis and atherosclerosis, based on the following article “AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate” in Science. 2019. There is mounting evidence that atherosclerosis is driven not just by dyslipidemia
Most DAMPs in inflammatory diseases are TLR2- and TLR4-ligands and according to the current concept, repeated stimuli would result in tolerance. Aims of the study were to verify this assumption, to investigate whether epigenetic effectors are involved and to explore the situation in rheumatoid arthritis (RA).
Patients with hypercholesterolemia have an increased risk for atherosclerotic cardiovascular disease, and despite lipid lowering with statins, an important residual risk remains. We hypothesize that this is due to persistent pro-inflammatory reprogramming of circulating monocytes. Monocyte derived macrophages are key components of atherosclerotic plaques. These cells can build a long-term pro-inflammatory phenotype after brief exposure
Over 50 participants attended the inspiring satellite-congress EAS 2019, co-organized by REPROGRAM, focused on the “Interplay of metabolism, inflammation and vascular biology”. On behalf of REPROGRAM Prof. Niels Riksen (Radboud UMC), Prof. Erik Stroes (Academic Medical Center) and Prof. Matthias Nahrendorf (Harvard Medical School) presented their work and emerging results. This symposium was open to
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N°667837.